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Overview:
About monoclonal antibody purification
The earliest work in the field of antibody purification dates back to 18th century. The discovery of antibodies can be tracked back to the work of Emil von Behring and Shibasaburo Kitasato in 1890. They demonstrated the existence of a substance in blood that conferred immunity against diphtheria toxin called “antitoxin”. The hybridoma approach was invented by Kohler and Milstein in 1975. This technique fused antibody producing plasma cells myeloma cells, to produce unlimited amount of specific antibody. Since the development of hybridoma technique many refinements have been made in the technique but the core concept remained the same.
Since chromatography was originally developed in 1900 by a Russian scientist named Mikhail Tsvet, the field of chromatography flourished along with the manufacture of monoclonal antibodies. However, protein A affinity chromatography was developed in 1968 by Pedro Cuatrecasas and Meir Wilchek. Since the early days of chromatography, monoclonal antibody purification has come a long way. Affinity, hydrophobic interaction, and ion exchange chromatography are all used together in the current procedure. Due to its excellent qualities, it has become a common procedure in the purification of monoclonal antibodies. It is still a widely used method for the purification of monoclonal antibodies.
To increase effectiveness, new technological advancements have been made in antibody purification. As an affordable alternative to protein A chromatography, nonionic detergent micelle aggregates are used, and multicolumn countercurrent solvent gradient purification (MCSGP) is used to boost the efficiency of typical affinity resins. Another technology utilized in the antibody purification process is precipitation. It is employed to eliminate a significant amount of contaminants. New filtering developments, such as multilayer depth filters, Nano filters, and new depth filters, have started to solve throughput and flexibility issues. Market insights indicate a significant growth potential of US$ 1 billion by the end of 2023 with a projected global demand of US$ 3 billion in the same year. The projected CAGR growth of 11% reflects the growing demand within the antibody purification market.
Scope
Patent and Scientific Literature Analysis
Our report provides in-depth analysis of types of chromatography used and the number of patents filled by the assignees
Scientific Literature Analysis
Our report shows chromatography combinations used in scientific literature for downstream processing of monoclonal antibodies
Types of Virus Removed
Our report shows the type of virus inactivated from patents and scientific literature studies.
Methods of virus inactivation
The report showcases the companies that are using virus inactivation methods
Virus inactivation detergents analysis
Our report shows the patents filed on the detergents used for virus inactivation, in downstream processing.
Virus Filtration Analysis
Our report summarises all scientific publications, products, and patents filed by the assignees.
Problems & Solutions Analysis
Our report identifies the problems and solutions in the monoclonal antibody purification process.
Company benchmarking
Our report shows the scoring parameters to identify the top companies. The report also demonstrates, ranking of four companies in which Asahi Kasie ranks highest and Sartorius ranks lowest.
Asahi Kasie Geographical Presence Analysis
Our report identifies the regions of Asahi Kasie filter production facilities.
Micro device suppliers of Asahi Kasie
Our report shows the countries and the contact details of Asahi Kasie micro device suppliers across the globe.
Filters manufactured by Asahi Kasie
Our report shows product portfolio for Asahi Kasie filters
Strategic activities
The report also showcases the strategic collaborations and acquisitions between companies from 2019 to 2022.
Report insights
Types of viruses inactivated during the virus removal process.
Benchmarking of technologies to identify top ranking companies.
Product portfolio of Asahi Kasie filters.
Strategic activities between companies.
Report highlights
In order to give the most precise estimations and forecasts, Wissen Research uses an extensive and iterative research approach that is focused on reducing deviation. The company blends top-down and bottom-up methodologies for market segmentation and quantitative estimation. In addition, data triangulation, which examines the market from three separate angles, is a recurrent topic present in all of our research studies. Important components of the approach used for all of our studies include the following.:
Preliminary data mining
On a wide scale, unprocessed market data is collected. Continuous data filtering makes sure that only verified and authenticated sources are taken into account. Additionally, data is extracted from a wide range of reports in our repository and from a number of reputable premium databases. We gather information from raw material suppliers, distributors, and purchasers to help with this since understanding the entire value chain is crucial for a thorough understanding of the market.
Surveys, technical symposia, and trade magazines are used to gather information on technical concerns and trends. Technical information focusing on white space and freedom of movement is also obtained from an intellectual property standpoint. Additionally, information on the industry’s drivers, constraints, and pricing patterns is obtained. As a result, a variety of original data are included in the material that is then cross-validated and certified with published sources.
Statistical model
We use simulation models to generate our market projections and estimates. Every study receives a special model that is tailored to it. Data for market dynamics, the technology environment, application development, and pricing patterns are gathered and supplied into the model all at once for analysis. The relative relevance of these factors is investigated, and their impact on the forecast period is assessed, using correlation, regression, and time series analysis. The process of market forecasting combines technological analysis with economic strategies, practical business acumen, and subject expertise.
Econometric models are frequently used for short-term forecasting, but technology market models are typically employed for long-term forecasting. These are based on a confluence of the business environment, regulatory environment, economic projection, and technical landscape. In order to develop global estimates, it is preferable to estimate markets from the bottom up by integrating data from key regional markets. This is required to ensure accuracy and a complete comprehension of the subject. Among the variables taken into account for forecasting are:
scenario for raw materials and supply versus pricing patterns
Regulations and anticipated developments
We give these criteria weights and use weighted average analysis to assess their market influence in order to calculate the anticipated market growth rate
Data Collection Matrix
Primary research | Secondary research |
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1.Introduction
1.1 Scope of monoclonal antibodies and definition
1.1.1 Objective of monoclonal antibodies
1.1.2 Technological categorization
1.1.3 Inclusion & exclusion
2.Overview of monoclonal antibodies
2.1 Components of monoclonal antibodies
2.2 Advantages
3.Technological analysis
3.1 Types of technologies used
3.2 Recent technologies
4.Patent analysis
4.1 Types of chromatography
4.1.1 Protein A Affinity chromatography + Cation-Exchange + Anion-Exchange chromatography
4.1.2 Cation-Exchange + Anion-Exchange + Size–Exclusion Chromatography
4.1.3 Cation-Exchange + Size-Exclusion Chromatography
4.2 Types of virus inactivation
4.3 Methods in virus activation
4.4 Detergents used in virus activation
4.5 Virus filtration
5.Scientific literature
5.1 Types of chromatography
5.1.1 Protein A Affinity + Cation-Exchange + Anion-Exchange chromatography
5.1.2 Cation-exchange + Size-exclusion chromatography
5.2 Methods in virus activation
5.3 Detergents used in virus activation
5.4 Virus filtration
6.Problems and solutions
7.Company benchmarking
7.1 Scoring parameters
7.2 Weightage parameters
7.3 Graphical representation of top players
8.Company portfolio
8.1 Geographical presence of Asahi kasie
8.2 Micro device suppliers of Asahi Kasie
8.3 Filters manufactured by Asahi Kasie
8.4 Newsletters
9.Market analysis
9.1 Geographical analysis
9.2 Drivers and restraints
9.3 Strategic activities
9.4 Key insights
10.Conclusion
S.no | Key Highlights of Report | |
1 | Patent Analysis | · Types of chromatography · Types of virus inactivation · Methods of virus activation · Detergents used in virus activation · Virus filtration |
2 | Market analysis | · Geographical analysis · Drivers and restraints · Strategic activities · Key insights |
3. | Company Portfolio | · Geographical presence of Asahi kasie · Micro device suppliers of Asahi Kasie · Filters manufactured by Asahi Kasie · Newsletters |
4. | Company benchmarking | · Scoring parameters · Weightage parameters · Graphical representation of top players |
5 | Scientific literature | · Types of chromatography · Methods of virus activation · Detergents used in virus activation · Virus filtration |
Figure number | Description |
1 | Type of chromatography used- through Patents |
2 | Type of chromatography used- through Scientific Literature |
3 | Types Of Viruses Inactivated/Filtered Out |
4 | Virus Inactivation- Detergents/Solvents Used |
5 | Types of Filter used for Virus Filtration |
6 | Geographical Analysis- Asahi Kasei |
7 | Ashai Kasei Filter Type |